RNS (responsive neurostimulation)

Implanted & surgical write · reads and writes

Responsive neurostimulation (RNS) is a closed-loop device implanted in the skull, with leads placed deep in the brain and/or as strips on its surface, each lead having four contacts. It records electrical brain activity from inside the skull (ECoG) between neighboring contacts, storing brief recordings and counts of when and where patient-specific seizure-like activity was detected. On detecting that activity, it delivers electrical stimulation to brain tissue at the seizure focus, hippocampal or neocortical depending on lead placement.

Spatial resolution

2.27–3 mm (two-source)

Temporal resolution

3 ms (inter-pulse interval)

Field of view

110–221 mm³ (sensing envelope)

Reads

intracranial ECoG brain activity

Writes

electrical stimulation

Destructive?

minimally destructive

Prerequisites

surgery: Implantation of a skull-mounted neurostimulator with electrodes placed directly into the seizure focus or foci.; other: Prior localization of one or two seizure foci by standard diagnostic testing; the pivotal trial enrolled adults 18-70 with at least three disabling seizures per month despite at least two antiseizure-drug trials.; other: A post-implantation stabilization period of the first four weeks, with sensing and recording enabled and stimulation disabled.

Theoretical spatial resolution

1 mm (two-source)

Theoretical temporal resolution

560 µs (inter-pulse interval)

Description

NeuroPace RNS is a cranially implanted closed-loop system for epilepsy. It continuously senses intracranial ECoG through depth and/or subdural cortical strip leads placed at identified seizure foci, each lead carrying four sensing and stimulating contacts. When it detects programmed, patient-specific epileptiform activity, it delivers brief electrical pulses to the brain tissue at the seizure focus to disrupt that activity before a seizure develops. It also works as a chronic ambulatory ECoG recorder, storing brief recordings and time and location detection counts for review.

Download the dataset (JSON, described by its JSON Schema).

Loading…