Electrophysiology · reads
A Neuropixels probe is a 10-mm silicon shank (70×20 µm in cross-section) inserted into brain tissue, carrying 960 closely spaced titanium nitride electrode sites, 384 of which can be used at once. It records extracellular signals from nearby neurons and splits each channel into a spike band (0.3–10 kHz) and a local field potential band (0.5–1000 Hz). Spike clusters isolated by their waveform timing and shape are read as one neuron or a very small number of neurons. Such probes have been used during human surgery and chronically in mice.
A Neuropixels-class probe inserts a 10-mm silicon shank (70×20 µm cross-section) carrying 960 closely spaced TiN microelectrode sites into brain tissue. Its 12×12 µm sites form a four-column checkerboard with 25 µm nearest-neighbor center spacing; 384 are simultaneously addressable. It records extracellular signals from nearby neurons, splitting each channel into spike/AP (0.3–10 kHz) and LFP (0.5–1000 Hz) bands. Such probes have been used intraoperatively in humans and chronically in freely moving mice. Neuropixels 2.0 places 1,280 sites on each 10 mm shank, and its four-shank version has 5,120 sites with 250 µm between shanks; two such probes give 10,240 sites, 768 of them recordable at once through one headstage. The ultra-dense NP Ultra layout has 5×5 µm TiN sites on a 768 × 8 grid at 6 µm center-to-center spacing.
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